发信人: Nowind (镜花水月), 信区: S_LifeScience
标 题: 田大成实验室PNAS文章online
发信站: 南京大学小百合站 (Tue Dec 4 07:59:51 2012)


http://www.pnas.org/content/early/2012/11/30/1211827110.abstract

Great majority of recombination events in Arabidopsis are gene conversion
events


Abstract

The evolutionary importance of meiosis may not solely be associated with
allelic shuffling caused by crossing-over but also have to do with its more
immediate effects such as gene conversion. Although estimates of the crossing-
over rate are often well resolved, the gene conversion rate is much less clear
. In Arabidopsis, for example, next-generation sequencing approaches suggest
that the two rates are about the same, which contrasts with indirect measures,
these suggesting an excess of gene conversion. Here, we provide analysis of
this problem by sequencing 40 F2 Arabidopsis plants and their parents. Small
gene conversion tracts, with biased gene conversion content, represent over 90
% (probably nearer 99%) of all recombination events. The rate of alteration of
protein sequence caused by gene conversion is over 600 times that caused by
mutation. Finally, our analysis reveals recombination hot spots and
unexpectedly high recombination rates near centromeres. This may be
responsible for the previously unexplained pattern of high genetic diversity
near Arabidopsis centromeres.


恭喜田老师










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※ 修改:．Nowind 於 Dec 4 08:02:01 2012 修改本文．[FROM: 114.212.232.27]
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