发信人: Avarice (observer_1), 信区: S_Chemistry
标 题: 祝贺我院再发一篇JACS
发信站: 南京大学小百合站 (Fri Jan 23 10:27:33 2015)
http://pubs.acs.org/doi/abs/10.1021/ja511420n
H2O2-Activatable and O2-Evolving Nanoparticles for Highly Efficient and
Selective Photodynamic Therapy against Hypoxic Tumor Cells
Huachao Chen , Jiangwei Tian , Weijiang He *, and Zijian Guo *
The low selectivity of currently available photosensitizers, which causes the
treatment-related toxicity and side effects on adjacent normal tissues, is a
major limitation for clinical photodynamic therapy (PDT) against cancer.
Moreover, since PDT process is strongly oxygen dependent, its therapeutic
effect is seriously hindered in hypoxic tumor cells. To overcome these
problems, a cell-specific, H2O2-activatable, and O2-evolving PDT nanoparticle
(HAOP NP) is developed for highly selective and efficient cancer treatment.
The nanoparticle is composed of photosensitizer and catalase in the aqueous
core, black hole quencher in the polymeric shell, and functionalized with a
tumor targeting ligand c(RGDfK). Once HAOP NP is selectively taken up by αvβ
3 integrin-rich tumor cells, the intracellular H2O2 penetrates the shell into
the core and is catalyzed by catalase to generate O2, leading to the shell
rupture and release of photosensitizer. Under irradiation, the released
photosensitizer induces the formation of cytotoxic singlet oxygen (1O2) in the
presence of O2 to kill cancer cells. The cell-specific and H2O2-activatable
generation of 1O2 selectively destroys cancer cells and prevents the damage to
normal cells. More significantly, HAOP NP continuously generates O2 in PDT
process, which greatly improves the PDT efficacy in hypoxic tumor. Therefore,
this work presents a new paradigm for H2O2-triggered PDT against cancer cells
and provides a new avenue for overcoming hypoxia to achieve effective
treatment of solid tumors.
--
※ 来源:．南京大学小百合站 http://bbs.nju.edu.cn [FROM: 210.28.143.87]
标 题: 祝贺我院再发一篇JACS
发信站: 南京大学小百合站 (Fri Jan 23 10:27:33 2015)
http://pubs.acs.org/doi/abs/10.1021/ja511420n
H2O2-Activatable and O2-Evolving Nanoparticles for Highly Efficient and
Selective Photodynamic Therapy against Hypoxic Tumor Cells
Huachao Chen , Jiangwei Tian , Weijiang He *, and Zijian Guo *
The low selectivity of currently available photosensitizers, which causes the
treatment-related toxicity and side effects on adjacent normal tissues, is a
major limitation for clinical photodynamic therapy (PDT) against cancer.
Moreover, since PDT process is strongly oxygen dependent, its therapeutic
effect is seriously hindered in hypoxic tumor cells. To overcome these
problems, a cell-specific, H2O2-activatable, and O2-evolving PDT nanoparticle
(HAOP NP) is developed for highly selective and efficient cancer treatment.
The nanoparticle is composed of photosensitizer and catalase in the aqueous
core, black hole quencher in the polymeric shell, and functionalized with a
tumor targeting ligand c(RGDfK). Once HAOP NP is selectively taken up by αvβ
3 integrin-rich tumor cells, the intracellular H2O2 penetrates the shell into
the core and is catalyzed by catalase to generate O2, leading to the shell
rupture and release of photosensitizer. Under irradiation, the released
photosensitizer induces the formation of cytotoxic singlet oxygen (1O2) in the
presence of O2 to kill cancer cells. The cell-specific and H2O2-activatable
generation of 1O2 selectively destroys cancer cells and prevents the damage to
normal cells. More significantly, HAOP NP continuously generates O2 in PDT
process, which greatly improves the PDT efficacy in hypoxic tumor. Therefore,
this work presents a new paradigm for H2O2-triggered PDT against cancer cells
and provides a new avenue for overcoming hypoxia to achieve effective
treatment of solid tumors.
--
※ 来源:．南京大学小百合站 http://bbs.nju.edu.cn [FROM: 210.28.143.87]
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