发信人: vonhabsburg (HRH The Duke of Aled KG GCB OM GCVO FRS), 信区: S_Chemistry
标 题: 王乐勇老师的最新一篇JACS
发信站: 南京大学小百合站 (Tue Jun 25 05:47:29 2013)
The drug delivery system based on supramolecular vesicles that were self-
assembled by a novel host-guest inclusion complex between a water-soluble
pillar[6]arene (WP6) and hydrophobic ferrocene derivative in water has been
developed. The inclusion complexation between WP6 and ferrocene derivative in
water was studied by 1H NMR, UV-Vis, and fluorescence spectroscopy, which
showed a high binding constant of (1.27 ± 0.42) × 105 M-1 with 1
:1 binding stoichiometry. This resulting inclusion complex could self-assemble
into supramolecular vesicles that displayed a significant pH-responsive
behaviour in aqueous solution, which were investigated by fluorescent probe
technique, dynamic laser scattering, and transmission electron microscopy.
Furthermore, the drug loading and in vitro drug release studies demonstrated
that these supramolecular vesicles were able to encapsulate mitoxantrone (MTZ)
to achieve MTZ-loaded vesicles, which particularly showed rapid MTZ release
at low pH environment. More importantly, the cellular uptake of these pH-
responsive MTZ-loaded vesicles by cancer cells was observed by living cell
imaging techniques, and their cytotoxicity assay indicated that unloaded
vesicles had low toxicity to normal cells, which could dramatically reduce the
toxicity of MTZ upon loading of MTZ. Meanwhile, MTZ-loaded vesicles exhibited
comparable anticancer activity in vitro as free MTZ to cancer cells under
examined conditions. This study suggests that such supramolecular vesicles
have great potential as controlled drug delivery systems.
--
※ 来源:．南京大学小百合站 http://bbs.nju.edu.cn [FROM: 163.1.253.165]
标 题: 王乐勇老师的最新一篇JACS
发信站: 南京大学小百合站 (Tue Jun 25 05:47:29 2013)
The drug delivery system based on supramolecular vesicles that were self-
assembled by a novel host-guest inclusion complex between a water-soluble
pillar[6]arene (WP6) and hydrophobic ferrocene derivative in water has been
developed. The inclusion complexation between WP6 and ferrocene derivative in
water was studied by 1H NMR, UV-Vis, and fluorescence spectroscopy, which
showed a high binding constant of (1.27 ± 0.42) × 105 M-1 with 1
:1 binding stoichiometry. This resulting inclusion complex could self-assemble
into supramolecular vesicles that displayed a significant pH-responsive
behaviour in aqueous solution, which were investigated by fluorescent probe
technique, dynamic laser scattering, and transmission electron microscopy.
Furthermore, the drug loading and in vitro drug release studies demonstrated
that these supramolecular vesicles were able to encapsulate mitoxantrone (MTZ)
to achieve MTZ-loaded vesicles, which particularly showed rapid MTZ release
at low pH environment. More importantly, the cellular uptake of these pH-
responsive MTZ-loaded vesicles by cancer cells was observed by living cell
imaging techniques, and their cytotoxicity assay indicated that unloaded
vesicles had low toxicity to normal cells, which could dramatically reduce the
toxicity of MTZ upon loading of MTZ. Meanwhile, MTZ-loaded vesicles exhibited
comparable anticancer activity in vitro as free MTZ to cancer cells under
examined conditions. This study suggests that such supramolecular vesicles
have great potential as controlled drug delivery systems.
--
※ 来源:．南京大学小百合站 http://bbs.nju.edu.cn [FROM: 163.1.253.165]
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