发信人: walking (一棵行走的树), 信区: S_Chemistry
标 题: 蒋锡群老师组新发JACS一篇
发信站: 南京大学小百合站 (Sat Feb 8 04:51:38 2014)
http://pubs.acs.org/doi/pdf/10.1021/ja411457r
Oligo(ethylene glycol)-Based Thermo-Sensitive Dendrimers and Their Tumor
Accumulation and Penetration
Wei Wu , Wouter Driessen ,and Xiqun Jiang
J. Am. Chem. Soc., Just Accepted Manuscript
DOI: 10.1021/ja411457r
Publication Date (Web): February 7, 2014
Abstract: Dendrimers have several featured advantages over other nanomaterials
as drug carriers, such as well-defined structure, specific low-nanometer size
and abundant peripheral derivable groups etc. However, these advantages have
not been fully exploited yet to optimize their biological performance,
especially tumor penetration that is a shortcoming of current nanomaterials.
Here we show the syntheses of a new class of oligo(ethylene glycol) (OEG)-
based thermo-sensitive dendrimers up to the 4th generation. Each dendrimer
shows monodisperse structure. OEG/poly(ethylene glycol) (PEG) with different
precise lengths were introduced respectively to the periphery of the 4th
generation dendrimer followed by an antitumor agent, gemcitabine (GEM). The
biodistributions of the GEM-conjugated dendrimers were investigated by micro
positron emission tomography and multispectral optoacoustic tomography imaging
techniques and compared with that of GEM-conjugated polyamidoamine (PAMAM).
The GEM-conjugated dendrimer with the longest peripheral PEG segments
exhibited the most desirable tumor accumulation and penetration and thus had
significantly higher antitumor activity than the GEM-conjugated PAMAM.
--
※ 来源:．南京大学小百合站 http://bbs.nju.edu.cn [FROM: 129.2.129.149]
标 题: 蒋锡群老师组新发JACS一篇
发信站: 南京大学小百合站 (Sat Feb 8 04:51:38 2014)
http://pubs.acs.org/doi/pdf/10.1021/ja411457r
Oligo(ethylene glycol)-Based Thermo-Sensitive Dendrimers and Their Tumor
Accumulation and Penetration
Wei Wu , Wouter Driessen ,and Xiqun Jiang
J. Am. Chem. Soc., Just Accepted Manuscript
DOI: 10.1021/ja411457r
Publication Date (Web): February 7, 2014
Abstract: Dendrimers have several featured advantages over other nanomaterials
as drug carriers, such as well-defined structure, specific low-nanometer size
and abundant peripheral derivable groups etc. However, these advantages have
not been fully exploited yet to optimize their biological performance,
especially tumor penetration that is a shortcoming of current nanomaterials.
Here we show the syntheses of a new class of oligo(ethylene glycol) (OEG)-
based thermo-sensitive dendrimers up to the 4th generation. Each dendrimer
shows monodisperse structure. OEG/poly(ethylene glycol) (PEG) with different
precise lengths were introduced respectively to the periphery of the 4th
generation dendrimer followed by an antitumor agent, gemcitabine (GEM). The
biodistributions of the GEM-conjugated dendrimers were investigated by micro
positron emission tomography and multispectral optoacoustic tomography imaging
techniques and compared with that of GEM-conjugated polyamidoamine (PAMAM).
The GEM-conjugated dendrimer with the longest peripheral PEG segments
exhibited the most desirable tumor accumulation and penetration and thus had
significantly higher antitumor activity than the GEM-conjugated PAMAM.
--
※ 来源:．南京大学小百合站 http://bbs.nju.edu.cn [FROM: 129.2.129.149]
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